Andrew J. Howard, Ph.D.
Associate Professor of BiologyAssociate Professor of Physics
Co-Director, Masters in Health Physics Program
BCPS Dept./ Biology Div.
Office: 174B Life Sciences Building
Office Hours:
Phone: 312.567.5881
Fax: 312.567.3576
Email:
howard@iit.edu
Web:
Howard's Web page
Expertise
- Macromolecular crystallographic methods development; biophysics
Education
- B.S, Pomona College (1975)
- Ph.D. Physics, University of California, San Diego (1981)
Curriculum Vitae
Research & Major Accomplishments
Research projects listed below and in the publication list.
Director of the American Crystallographic Association's Summer School in Macromolecular Crystallography since 2003; IIT has educated about 100 graduate students, postdocs, and industrial scientists from around the world in this school.
Co-Director (with Dr. Laurence Friedman) of IIT's Professional Masters Program in Health Physics. This is the largest graduate program in Health Physics in the US. There are about seventy students active in the program.
Current Projects
- Development of X-GEN, a crystallographic data processing software package
- Optimization of a Vitreoscilla hemoglobin protein-expression plasmid (Park et al (2003), Plasmid 50:169)
- Structural studies of spin states in Pseudomonas cytochrome C peroxidase
- Structural studies of cholera toxin in complex with human ARF-6 protein
- Structural genomics studies of proteins from Haemophilus
- Structural genomics studies of multiple-splice variants
- Beamline software development at Southeast Regional Collaborative Access Team
Awards/Honors
- Elected member, Data Standards & Computing Committee of the American Crystallographic Association (current)
- Founding chair, Advanced Photon Source CAT Directors' Council (1997-1999)
- Chair, Gordon Conference on Diffraction Methods in Molecular Biology, 2000
Patents
Books
Selected Publications
Celia C. H. Chen, Ying Han, Weiling Niu, Anna N. Kulakova, Andrew Howard, John P. Quinn, Debra Dunaway-Mariano, Osnat Herzberg (2006), Structure and Kinetics of Phosphonopyruvate Hydrolase from Voriovorax sp. Pal2: New Insight into the Divergence of Catalysis within the PEP Mutase/Isocitrate Lyase Superfamily, Biochemistry-US 45: 11491-11504.
Jin, T., Guo, F., Kim, S., Howard, A., Zhang, Y. (2007), X-ray crystal structure of TNF ligand family member TL1A at 2.1Å, Biochem. Biophys. Res. Commun. 364: 1-6.
Teplyakov,A., Lim,K., Zhu,P.P., Kapadia,G., Chen,C.C.H., Schwartz,J., Howard,A., Reddy,P.T., Peterkofsky,A., and Herzberg,O. (2006) Structure of phosphorylated enzyme I, the phosphoenolpyruvate:sugar phosphotransferase system sugar translocation signal protein, Proc.Natl.Acad.Sci. 103: 16218-16223.
Hoang, Q., Sicheri, F., Howard,A., Yang,D. (2003) Bone recognition mechanism of porcine osteocalcin from crystal structure. Nature 425: 977-980.
Howard, A. (2002) Macromolecular crystallography at third-generation synchrotron sources. Chapter for Third Generation Hard X-ray Synchrotron Radiation Sources: Source Properties, Optics, and Experimental Techniques. D.M. Mills, ed. Wiley: 406pp.
Eisenstein, E., Gilliland, G.L., Herzberg, O., Moult, J., Orban, J., Poljak, R.J., Banerjei, L., Richardson, D., and Howard, A.J. (2000) Biological function made crystal clear - annotation of hypothetical proteins via structural genomics. Current Opinions in Biotechnology 11: 25-30.
Howard, A. (1998) Participation of pharmaceutical companies in synchrotron radiation research. Nature Structural Biology 5: 623-626.
Howard, A.J. (2000) Data processing in macromolecular crystallography. Chapter in: Crystallographic Computing 7: Proceedings from the Macromolecular Crystallographic Computing School, 1996. P.E. Bourne and K.D. Watenpaugh, eds. Oxford: Oxford University Press.
Howard, A.J. and Poulos, T.L., (1992) Methods in macromolecular crystallography. chapter in Advances in Biophysical Chemistry2: 1-36.
Howard, A.J. Gilliland, G.L., Finzel, B.C. Poulos, T.L. Ohlendorf, D.H. and Salemme, F.R. (1987) Use of an imaging proportional counter in macromolecular crystallography. J. Applied Crystallogr.20: 383:387.
