Joseph Orgel, Ph.D.
Assistant Professor of BiologyAssoc. Director of Fiber Crystallography BioCAT
BCPS/ Biology Division
Office: 146D Life Sciences Building
Office Hours:
Phone: 312.567.3398
Fax: 312.567.3494
Email:
orgel@iit.edu
Web:
Joseph Orgels's webpage
Expertise
- Extracellular matrix biology and collagen structure, transmembrane protein structure, Macromolecular and fiber crystallography
Education
- B.Sc, University of Stirling
- Ph.D, University of Stirling
Curriculum Vitae
Research & Major Accomplishments
The lab also deals with protein folding and aggregation of biological polymers and membrane surface active helices (see the HHELIX server).
Orgel Lab home page.
He has made several significant contributions to the understanding of collagen structure and is an acknowledged leader in the fields of extracellular matrix structure and fiber diffraction. He was awarded an NSF CAREER award: “Molecular Structure of Collagen Type II by Fiber Crystallography” and inducted to the editorial board of the Public Library of Science journal PLoS ONE in 2007. Recently the Orgel lab has been working to produce in situ visualizations of collagen-ligand interactions at the collagen fibril surface using fiber diffraction and electron microscopy (refs 1 and 5 below, both appearing in the Proceedings of the National Academy of Sciences).
Current Projects
- Collagen and ECM structure.
Awards/Honors
Patents
Books
Selected Publications
Orgel JP. Surface-active helices in transmembrane proteins. Curr Protein Pept Sci. 2006 Dec;7(6):553-60. Review.
Orgel JP, Irving TC, Miller A, Wess TJ. Microfibrillar structure of type I collagen in situ. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9001-5.
Lazar KL, Miller-Auer H, Getz GS, Orgel JP, Meredith SC. Helix-turn-helix peptides that form alpha-helical fibrils: turn sequences drive fibril structure. Biochemistry. 2005 Sep 27;44(38):12681-9.
Orgel JP. Sequence context and modified hydrophobic moment plots help identify 'horizontal' surface helices in transmembrane protein structure prediction. J Struct Biol. 2004 Oct;148(1):51-65.
Orgel JP, Miller A, Irving TC, Fischetti RF, Hammersley AP, Wess TJ. The in situ supermolecular structure of type I collagen. Structure. 2001 Nov;9(11):1061-9.
“Collagen fibril architecture, domain organization and triple-helical conformation governs its proteolysis”. Shiamalee Perumal, Olga Antipova, Joseph P.R.O. Orgel In Pres for Proc Natl Acad Sci U S A. 2008.
“Type I collagen and collagen mimetics as angiogenesis promoting superpolymers”. Twardowski, T., Fertala, A., Orgel, J.P.R.O., and San Antonio, J. D. In Press Curr. Pharm. Des. 2007.
“Flanking polyproline sequences inhibit β-sheet structure in polyglutamine segments by inducing PPII-like helix structure”. Gregory Darnell, Joseph Orgel, Reinhard Paul, and Stephen Meredith. Journal of Molecular Biology. 374, 688-704 (2007).
Professional Society Memberships
- American Chemical Society, 2000-present
- American Crystallographic Association, 2002-present
- Sigma XI, 2005-present
