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    Armour Faculty

    Jialing Xiang, Ph.D.

    Assistant Professor of Biology

    Office: 396 Life Sciences Building
    Office Hours:
    Phone: 312.567.3491
    Fax: 312.567.3494
    Email: xiang@iit.edu
    Web:

    Expertise

    Education

    • M.D, Xuzhou Medical College
    • Ph.D, University of Alabama, Birmingham

    Curriculum Vitae

    Research & Major Accomplishments

    The work in my laboratory is focused on the molecular mechanisms of cancer and its potential therapy. Cancer is characterized by uncontrolled cell growth, which results from unlimited proliferation and malfunction of programmed cell death (apoptosis). Apoptosis is an essential process both in normal development and in homeostasis, removing unwanted cells. It is recognized that apoptosis plays a critical role in the development and progression of cancer. The apoptotic process is regulated by many genes, including the Bcl-2 family. The Bcl-2 family contains pro-apoptotic molecules such as Bax and Bak, and anti-apoptotic molecules such as Bcl-2 and Bcl-xL. We use the pro-apoptotic Bax molecule as a model system to study the role of the apoptotic machinery in the development of cancer.

    We are currently studying the Bax-mediated apoptotic pathway and its associated signal-transduction network in the progression of prostate cancer using both in vitro and in vivo prostate cancer model systems. Additionally, we are also interested in the cross-talk among the different signaling pathways. We believe that understanding the apoptotic signaling mechanism of cancer cells should shed light on our understanding of the cancer development and may provide information critical for treatment and prevention of cancers.

    Current Projects

    Awards/Honors

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    Jialing Xiang
    Department of Biological, Chemical, and Physical Sciences

    Cell death is a normal body function. Each day, cells repair themselves or commit suicide and die. About 15 years ago, researchers began to look more closely at it for clues to diseases involving abnormal cell death, like cancer. more...

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