Kenneth W. Stagliano, Ph.D.
Associate Professor of Chemistry
Office: 354 Life Sciences Building
Office Hours:
Phone: 312.567.3428
Fax: 312.567.3494
Email:
stagliano@iit.edu
Web:
Expertise
Education
- B.S, Temple University
- Ph.D, Temple University
Curriculum Vitae
Research & Major Accomplishments
The focus of our research group is on the development of new chemical reactions for solving regiochemical and stereochemical problems for the total synthesis of biologically active natural products. First, a target molecule is chosen based on its unique chemical structure and biological activity. The molecule is then systematically disconnected into commercially available building blocks (chemicals) by the process of retrosynthetic analysis. The building blocks are then put together in the laboratory by chemical reaction eventually leading to the target molecule - hopefully, in higher yield than what nature could produce. Representative target molecules include the HIV inhibitor, conocurvone and quinone alkaloids including aulosirazole The development of new synthetic methods which will have wide applicability in the pharmaceutical and materials industry, including the development of new palladium catalyzed reactions, are also major areas of research in our group.
Current Projects
Awards/Honors
Patents
Books
Selected Publications
- "Regioselective Directed ortho Metalation of 3H-Naphtho[2,1-b]pyrans. Synthesis of Methylteretefiolione B. Stagliano, K. W.; Malinakova, H.C. Tetrahedron Letters 1998, 39, 4941-4944.
- "Synthesis of Contiguously Substituted Nitro Aromatics via Directed Ortho Metalation Nitration" Stagliano, K. W.; Malinakova, H.C.; Takayama, A. Synthetic Communications 1997, 27, 2413-2418.
- "Regiospecific Synthesis of Unsymmetrical 2,3-Diarlquinones via Stepwise Pd(0)-Catalyzed Couplings of Arylstannanes to Doubly Activiated Quinone Equivalents" Stagliano, K. W.; Malinakova, H.C. Tetrahedron Letters 1997, 38, 6617-6620.
- "Directable Regiochemistry in Naphthazarins via the Use of Masked Derivatives", Bloomer, J.L.;Stagliano,Tetrahedron Letters 1993, 34(5), 757-760.
- "Preparation of Functionalized Julonge Acetates and Julonges via 1,4 - Dimethoxynaphthalene Derivatives: Synthesis of Anthraquinones Related to Rhein and Aloe-emodin" Bloomer, J.L.;Stagliano, K.W. and Gazzillo, J.A. Journal of Organic Chemistry 1993, 58(27) 7906-7912
