David J. Mogul, Ph.D.Interim Chair, Department of Biomedical Engineering
Office: Engineering Research Building, Room 110N
Mailing address: Wishnick Hall, Suite 314
3255 S Dearborn St
Chicago, IL 60616-3793
Web: Brain Electrophysiology Lab
- Brain electrophysiology, chaos control of epilepsy, cellular and network behavior
- B.S., Electrical Engineering, Cornell University
- M.S., Electrical Engineering/Computer Science, Northwestern University
- Ph.D., Electrical Engineering/Computer Science, Northwestern University
- Postdoctoral Fellow, Pharmacology & Physiology, University of Chicago
Professor Mogul's research can be summarized as the study of the electrophysiology and electrical dynamics of the brain. His laboratory has applied a quantitative approach toward understanding neuronal physiology using both conventional and novel experimental techniques at the cellular and systems levels. The specific part of the brain that Professor Mogul's laboratory has been predominantly investigating has been the hippocampus, a small organ in the limbic region that is essential for learning and long-term memory formation and which is a major focal site for the etiology of a number of pathological conditions such as epilepsy and Alzheimer's disease. More specifically, his research group has been engaged in studying a wide variety of related phenomena in this region including membrane biophysics, plasticity of neurotransmission, and nonlinear network characteristics underlying normal and diseased behavior.
MOGUL, D.J. & A.P. Fox. Evidence for multiple types of Ca2+ channels in acutely isolated hippocampal CA3 neurones. J. Physiol.(Lond.) 433: 259-281, 1991.
Artalejo, C.R., D.J. MOGUL, R. Perlman, & A.P. Fox. Three types of bovine chromaffin cell Ca2+ channels: Facilitation increases the opening probability of a 27 pS channel. J. Physiol. (Lond.) 444: 213-240, 1991.
MOGUL, D.J., M.E. Adams, & A.P. Fox. Differential activation of adenosine receptors decreases N-type but potentiates P-type Ca current in hippocampal CA3 neurons. Neuron. 10: 327-334, 1993.
Dave, S. & D.J. MOGUL. ATP receptor activation potentiates a voltage-dependent Ca channel in hippocampal neurons. Brain Res. 715: 208-216, 1996.
Disterhoft, J.F., L.T. Thompson, J.R. Moyer, & D.J. MOGUL. Calcium-dependent afterhyperpolarization and learning in young and aging hippocampus. Life Sci. 59: 413-420, 1996.
Kessey, K., B.L. Trommer, L. Overstreet, T. Ji & D.J. MOGUL. A role for adenosine A2 receptors in the induction of long-term potentiation in the CA1 region of rat hippocampus. Brain Res. 756: 184-190, 1997.
Fleming K.M. & D.J. MOGUL. Adenosine A3 receptors potentiate hippocampal calcium current by a PKA-dependent/PKC-independent pathway. Neuropharmacology. 36: 353-362, 1997.
Kessey, K. & D.J. MOGUL. NMDA independent LTP by adenosine A2 receptor-mediated postsynaptic AMPA potentiation in hippocampus. J. Neurophysiol. 78: 1965-1972, 1997.
Kessey, K. & D.J. MOGUL. Adenosine A2 receptors modulate hippocampal synaptic transmission via a cAMP-dependent pathway. Neuroscience. 84: 59-69, 1998.
Slutzky, M.W., Cvitanovic, P., & D.J. MOGUL. Deterministic chaos and noise in three in vitro hippocampal models of epilepsy. Annals of Biomedical Engineering 29:7-13, 2001.
Slutzky, M.W., Cvitanovic, P., & D.J. MOGUL. Identification of determinism in noisy neuronal systems. Journal of Neuroscience Methods.118: 153-161, 2002.
Slutzky, M.W., Cvitanovic, P., & D.J. MOGUL. Manipulating epileptiform bursting in the rat hippocampus using chaos control and adaptive techniques. IEEE Transactions on Biomedical Engineering. 50: 559-570, 2003.
Colpan ME, Sekerci Z, Hekimoglu B, & D.J. MOGUL. Computer-assisted intraaneurysmal thrombus visualization. J Neuroimaging. 16(1): 59-68, 2006.
Colpan ME, Sekerci Z, Cakmakci E, Donmez T, Oral N, & D.J. MOGUL. Virtual endoscope-assisted intracranial aneurysm surgery: evaluation of fifty-eight surgical cases. Minimally Invasive Neurosurgery. 50(1): 27-32, 2007.
Li Y & D.J. MOGUL. Electrical control of epileptic seizures. J. Clinical Neurophysiology. 24(2): 197-204, 2007.
Colpan ME, Li Y, Dwyer J, & D.J. MOGUL. Proportional feedback stimulation for seizure control in rats. Epilepsia. 48(8): 1594-1603, 2007.
Li, Y., Nicolaescu, I., Colpan, M.E. & D.J. MOGUL. Neuronal desynchronization as a trigger for seizure generation. IEEE Transactions on Neural Systems & Rehabilitation Engineering. 16(1): 2008.
Chen, M. & D.J. MOGUL. A structurally-detailed finite element human head model containing both macro- and microscopic elements for simulation of transcranial magnetic stimulation. J. Neurosci. Meth. 179 (1): 111-120, 2009.
Chen, M. & D.J. MOGUL. Using increased structural detail of the cortex to improve the accuracy of modeling the effects of transcranial magnetic stimulation on neocortical activation. IEEE Trans. Biomed Engr. 57: 1216-1226, 2010
Fine, A.S., Nicholls, D.P. & D.J. MOGUL. Calculating instantaneous synchrony of nonlinear nonstationary oscillators in the brain. J. Neurosci. Meth. 186: 42-51, 2010
Slutzky, M.W., Jordan, L.R., Krieg, T., Chen, M., MOGUL, D.J. & L. Miller. Optimal spacing of surface electrode arrays for brain machine interface applications. J. Neural Engineering. 7 (2):, 2010.