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    Georgia Papavasiliou, Ph.D. - Assistant Professor

    Georgia Papavasiliou, Ph.D.

    Assistant Professor

    Office: Wishnick Hall, Room 222
    Wishnick Hall, Suite 314
    3255 S Dearborn St
    Chicago, IL 60616-3793

    Phone: 312.567.5959
    Fax: 312.567.5707
    Email: papavasiliou@iit.edu
    Web:
         

    Expertise

    • Tissue engineering, cell biomaterial interactions, polymer reaction engineering, computational modeling of branched and crosslinked polymer systems

    Education

    • B.S., Chemical Engineering, Illinois Institute of Technology, 1996
    • Ph.D., Chemical Engineering, Illinois Institute of Technology, 2003

    Research

    Our research focuses on the coupling of computational models of hydrogel formation and experimental design for the synthesis of hydrogel nanoparticle delivery vehicles and the fabrication of synthetic hydrogel extracellular matrix analogues with tunable degradation rates, incorporated biofunctionality, and mechanical properties for guiding cell behavior and tissue regeneration.  We hypothesize that dynamic kinetic models of polymerization and gelation provide a bottom-up engineering approach to effectively guide in the experimental design and optimization of biomaterial properties for regenerative medicine applications. 

    Current Research Projects

    • Quantitative analysis of the effects of biofunctional and physical gradients on endothelial cell behavior in poly(ethylene glycol) diacrylate hydrogels 
    • Independent tuning of matrix properties for controlled invasion and vessel formation within matrix metalloproteinase-sensitive PEG hydrogels   
    • Effects of growth factor loaded PEG nanoparticles on cell invasion and vascularization within synthetic PEG ECM analogues   
    • Crosslinked PEG nanoparticles for sustained delivery of phosphate ions to the intestinal mucosa 
    • Computational modeling of hydrogel crosslinking via free-radical photopolymerization for the prediction of PEG ECM analogue biomaterial properties

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    Research Funding 
    NIH R21 (HL094916-01A1)  ERIF  Pritzker Institute of Biomedical Science and Engineering

    Current Projects

    Awards/Honors

    • IIT Research Fellow, 1996
    • AIChE Chicago Section McCormick Award Recipient, 1996
    • University Excellence in Teaching Award, IIT, 1998
    • W.M. Langdon Excellence in Chemical Engineering Teaching Award, IIT, 1998
    • University Excellence in Teaching Award-Illinois Institute of Technology, 2012
    • Tissue Engineering and Regenerative Medicine Society, 2nd Place Graduate Student Research Poster Competition, Houston Texas, December 2012

    Patents

    Books

    Selected Publications


    Peer Reviewed Publications

    Sokic S, Larson JC, Larkin S, Papavasiliou G, Holmes T, Brey EM. Label-Free Nondestructive Imaging of Vascular Network Structure in 3D Culture. Microvascular Research (in revision)

    Lee C, Teymour F, Camastral H, Tirreli N, Hubbell JA, Elbert DL, Papavasiliou G. Characterization of the Network Structure of PEG-diacrylate Hydrogels Formed in the Presence of Vinyl Pyrrolidone (in preparation)

    Turturro MV, Christenson MC, Larson JC, Young DA, Brey EM, Papavasiliou G. MMP-Sensitive PEG Diacrylate Hydrogels with Spatial Variations in Matrix Properties Stimulate Directional Vascular Sprout Formation. PLoS ONE. 8(3):e58897;2013

    Turturro MV, Sokic S, Larson JC and Papavasiliou G. Effective Tuning of Ligand Incorporation and Mechanical Properties in Visible Light Photopolymerized Poly(ethylene glycol) Diacrylate Hydrogels Dictates Cell Adhesion and Proliferation. Biomedical Materials. 8(2): 25001-25012, 2013.

    Turturro MV, Vélez Rendón DM, Teymour F, Papavasiliou G. A Kinetic Investigation of PEG Hydrogel Formation via Perfusion Based Frontal Photopolymerization:  Influence of Free Radical Polymerization Conditions on Frontal Velocity and Swelling Gradients. Macromolecular Reaction Engineering. 7(2): 107-115, 2013
    (Featured in Cover)

    Sokic S, Papavasiliou G. Controlled Proteolytic Cleavage Site Presentation in Biomimetic PEGDA Hydrogels Enhances Neovascularization In Vitro. Tissue Engineering Part A. 18(23-24):2477-2486, 2012

    Sokic S, Papavasiliou G. FGF-1 and Proteolytically-mediated Cleavage Site Presentation Influence 3D Fibroblast Invasion in Biomimetic PEGDA Hydrogels. Acta Biomaterialia. 8(6):2213-2222, 2012

    Turturro MV, Papavasiliou G. Generation of Mechanical and Biofunctional Gradients in PEG Diacrylate Hydrogels by Perfusion-Based Frontal Photopolymerization. Journal of Biomaterials Science Polymer Edition. 23(7): 917–939, 2012

    Papavasiliou G, Cheng MH, Brey EM. Strategies for Vascularization of Polymer Scaffolds. Journal of Investigative Medicine. 58(7): 838-844, 2010

    Papavasiliou G, Songprawat P, Pérez-Luna VH, Hammes EA, Morris M, and Brey EM. Three Dimensional Patterning in Poly(ethylene glycol) Hydrogels Through Surface Initiated Photopolymerization. Tissue Engineering Part C:  Methods. 14(2): 129-140, 2008  

    Kizilel S, Papavasiliou G, Gossage J, Teymour F. Mathematical Model for Vinyl Divinyl Polymerization. Macromolecular Reaction Engineering. 1(3): 587-603, 2007 

    PhD Publications

    Papavasiliou G, Teymour F. Bifurcation Analysis of Non-isothermal Nonlinear Polymerization. Industrial & Engineering Chemistry Research. 44(8): 2754-2766, 2005

    Papavasiliou G, Teymour F.  Reconstruction of the Chain Length Distribution for Vinyl Divinyl Copolymerization Using the Numerical Fractionation Technique. Macromolecular Theory & Simulations. 12(8): 543-548, 2003 

    Papavasiliou G, Birol I, Teymour F.  Calculation of Molecular Weight Distributions in Non-linear Free-Radical Polymerization Using the Numerical Fractionation Technique. Macromolecular Theory and Simulations. 11(5): 533-548, 2002 

    Undergraduate Publications

    Shao S, Papavasiliou G, and Arastoopour, H.  Laser Doppler Anemometry (LDA) Diagnostics of the Two Phase Flow Parameters in a Liquid-Gas Two-Phase Flow System.  AIChE Symposium Series, Advances in Fluidization and Fluid Particle Systems. 93( 317): 7-11, 1997.

    Book Chapters

    Georgia Papavasiliou. Gradient Scaffolds for Vascularized Tissue Formation. In Vascularization: Regenerative Medicine and Tissue Engineering. CRC Press (In Preparation)

    Papavasiliou G, Sokic S, Turturro MV. Synthetic PEG Hydrogels as Extracellular Matrix Mimics for Tissue Engineering Applications. Biotechnology/Book 3, Reda Sammour (Ed.). ISBN 979-953-307-738-2, InTech, 2011  

    Papavasiliou G, Teymour F. Nonlinear Dynamics in Continuous Stirred Tank Reactor Polymerization. Chap. 24, in Nonlinear Dynamics in Polymeric Systems, edited by John A. Pojman and Qui Tran-Cong-Miyata. Vol 869: 309-323. Washington, DC: American Chemical Society, 2004

    Professional Society Memberships