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    Institute for
    Food Safety
    and Health

    Illinois Institute of Technology
    Moffett Campus
    6502 South Archer Rd.
    Bedford Park, IL 60501-1957
    (P) 708.563.1576

    Indika Edirisinghe, PhD

    Senior Scientist-Biochemistry, Manager-Nutrition Programs,
    Assistant Professor
    Department: IFSH/IIT, Clinical Nutrition Research Center


    Contact Information

    Institute of Food Safety and Health
    6502 South Archer Road
    Bedford Park, IL-60501
    Room #335

    Ph:   708-563-8178
    Cell: 708-308-0173

    Email:
    iedirisi@iit.edu

    Biographical Profile

    Dr. Edirisinhe's backround relates to the following areas: The effect of polyphenolic compound on endothelial function, blood pressure regulation, platelet function, insulin resistance, inflammatory and oxidative stress responses during acute and chronic interventions. The research approach includes human cell culture, animal models and human clinical trials.

    Expertise

    Clinical Nutrition, Nutritional Biochemistry, Endothelial function. Molecular Nutrition

    Education

    PhD In Biochemistry and Molecular Biology
    MS In Biochemistry and Molecular Biology
    BS in Zoology

    Research Focus

    Dr. Edirisinhe's research is focused on investigating the effects of dietary constituents on vascular disease including evaluation of endothelium function, inflammatory and oxidative stress responses during acute and chronic interventions. The research approach includes in vivo human studies as well as in vitro human cell culture models.

    Teaching

    FPE-FST-401/FPE-FST-501  Nutrition and Metabolism

    Current Projects

    1. Define the mechanism of plant flavonoid on oxidative stress- and inflammatory-mediated insulin resistance in-vitro in human muscle and adipose tissues.

    2. Effect of grape seed extract delivered in a beverage on blood pressure in individuals with pre-hypertension.

    3. Effect of strawberry on oxidative stress- and inflammatory-mediated insulin resistance (IR) in humans: Combating a major risk factor for diabetes and cardiovascular disease through diet.

    4. Effect of Fruit Antioxidants on Insulin Resistance-Mediated Endothelial Dysfunction.

    Selected Publications

    1. Burton-Freeman B, Talbot J, Park E, Krishnankutty S, Edirisinghe I. Protective activity of processed tomato products on postprandial oxidation and inflammation: A clinical trial in healthy weight men and women. Mol Nutr Food Res. 2012 Feb 14. doi: 10.1002/mnfr.201100649. [Epub ahead of print] PubMed PMID: 22331646.

    2. Tadapaneni RK, Banaszewski K, Patazca E, Edirisinghe I, Cappozzo J, Jackson L, Burton-Freeman B. Effect of High-Pressure Processing and Milk on the Anthocyanin composition and Antioxidant Capacity of Strawberry-Based Beverages. J Agric Food Chem. 2012 Jan 17. [Epub ahead of print] PubMed PMID: 22224588.

    3. Edirisinghe I, Banaszewski K, Cappozzo J, McCarthy D, Burton-Freeman BM. Effect of black currant anthocyanins on the activation of endothelial nitric oxide synthase (eNOS) in vitro in human endothelial cells. J Agric Food Chem. 2011 Aug 24;59(16):8616-24. Epub 2011 Jul 28. PubMed PMID: 21761876.

    4. Edirisinghe I, Banaszewski K, Cappozzo J, Sandhya K, Ellis CL, Tadapaneni R, Kappagoda CT, Burton-Freeman BM. Strawberry anthocyanin and its association with postprandial inflammation and insulin. Br J Nutr. 2011 Sep;106(6):913-22. Epub 2011 May 16. PubMed PMID: 21736853.

    5. Ellis CL, Edirisinghe I, Kappagoda T, Burton-Freeman B. Attenuation of meal-induced inflammatory and thrombotic responses in overweight men and women after 6-week daily strawberry (Fragaria) intake. A randomized placebo-controlled trial. J Atheroscler Thromb. 2011;18(4):318-27. Epub 2011 Jan 13. PubMed PMID: 21242652.

    6. Edirisinghe I, Rahman I. Cigarette smoke-mediated oxidative stress, shear stress, and endothelial dysfunction: role of VEGFR2. Ann N Y Acad Sci. 2010 Aug;1203:66-72. Review. PubMed PMID: 20716285.

    7. Edirisinghe I, Arunachalam G, Wong C, Yao H, Rahman A, Phipps RP, Jin ZG, Rahman I. Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells. Antioxid Redox Signal. 2010 Jun 15;12(12):1355-69. PubMed PMID: 19929443; PubMed Central PMCID: PMC2864667.

    8. Zakkar M, Van der Heiden K, Luong le A, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I, Rahman I, Carlsen H, Haskard DO, Mason JC, Evans PC. Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1851-7. Epub 2009 Sep 3. PubMed PMID: 19729611.

    9. Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F, Kappagoda T. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. 2009 Dec;58(12):1743-6. Epub 2009 Jul 15. PubMed PMID: 19608210.

    10. Edirisinghe I, Burton-Freeman B, Varelis P, Kappagoda T. Strawberry extractcaused endothelium-dependent relaxation through the activation of PI3 kinase/Akt. J Agric Food Chem. 2008 Oct 22;56(20):9383-90. Epub 2008 Sep 25. PubMed PMID: 18816058.

    11. Edirisinghe I, Yang SR, Yao H, Rajendrasozhan S, Caito S, Adenuga D, Wong C, Rahman A, Phipps RP, Jin ZG, Rahman I. VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. FASEB J. 2008 Jul;22(7):2297-310. Epub 2008 Feb 8. PubMed PMID: 18263699.

    12. Edirisinghe I, Burton-Freeman B, Tissa Kappagoda C. Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract. Clin Sci (Lond). 2008 Feb;114(4):331-7. PubMed PMID: 17927567. 13. Hallam KM, Edirisinghe I, Balasuriya UB, Gunawardena S, Bravo EM, Ravi K, Kappagoda CT. Effects of mitral regurgitation on the reflex diuresis to pulmonary lymphatic obstruction in rabbits. Exp Lung Res. 2007 Jun-Jul;33(5):259-75. PubMed PMID: 17620187.

    14. Edirisinghe I, McCormick Hallam K, Kappagoda CT. Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta. Clin Sci (Lond). 2006 Aug;111(2):145-51. PubMed PMID: 16524362.

    For a complete list of publications click here.

    Presentations

    Berry Symposium 2011 - Effect of Fruit Antioxidant on Endothelial Function

    Society Memberships, Conferences, and Activities

    1. Society of Free Radical Biology and Medicine

    2. The American Physiological Society

    3. Society for food science and technology

    4. Obesity Society

    5. Society for the Study of Ingestive Behavior

    6. Faculty of 1000 Medicine Section


    Last modified: 02/26/2014 19:24:42

    Institute for Food Safety and Health | Illinois Institute of Technology | Moffett Campus
    6502 South Archer Rd. Bedford Park, IL 60501-1957 (P) 708.563.1576