Konstantinos Arfanakis, assistant professor of biomedical engineering and member of the Medical Imaging Research Center, and the Center for Integrative Neuroscience and Neuroengineering Research, is an innovative researcher in the areas of the development of magnetic resonance imaging (MRI) data acquisition, image reconstruction, and data analysis techniques, and the application of these methods for the diagnosis and monitoring of neurological disease.
With peer-reviewed research funding from agencies including the National Institutes of Health, the Alzheimer’s Association, and other foundations and centers, Dr. Arfanakis has been able to show that measurements of water diffusion can be used to detect abnormalities in the temporal lobes of patients with mild cognitive impairment (often a precursor of Alzheimer’s disease). This is a step closer to developing an MRI technique for early diagnosis of Alzheimer’s disease.
One of Dr. Arfanakis’ breakthroughs occurred in the detection of diffuse axonal injury (DAI) lesions. DAI lesions produced as a result of mild traumatic brain injury, are not detectable by means of conventional MRI, computed tomography, or any other available imaging technique. Arfanakis was the first to develop an MRI method that allows detection of DAI lesions in patients with mild traumatic brain injury. This work has been cited in more than 100 peer-reviewed journal articles.