Joseph Orgel Assistant Professor of Biology Academic Editor PLoS ONE Assoc. Director of Fiber Crystallography BioCAT
	B.Sc.:	University of Stirling
	Ph.D.:	University of Stirling
	Office:	146D Life Sciences Building
	Phone:	312.567.3398       Fax:  312.567.3494
	e-mail:	orgel@iit.edu

Professional Interests

My research interests are concerned with fundamental structural biochemistry problems that have direct links to the understanding and treatment of disease, primarily of the extra cellular matrix of mammals. The principal techniques for study being: X-ray fiber diffraction and crystallography.

The lab also deals with protein folding, aggregation of biological polymers and membrane surface active helices (see the HHELIX server).

Orgel Lab home page.

Representative Publications

• Shiamalee Perumal, Olga Antipova, Joseph P.R.O. Orgel “Collagen fibril architecture, domain organization and triple-helical conformation govern its proteolysis”. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8): p2824-2829
  
  
• “Flanking polyproline sequences inhibit β-sheet structure in polyglutamine segments by inducing PPII-like helix structure”. Gregory Darnell, Joseph Orgel, Reinhard Paul, and Stephen Meredith. Journal of Molecular Biology. 2007; 374: p688-704.
  
  
• Orgel JP. Surface-active helices in transmembrane proteins. Curr Protein Pept Sci. 2006 Dec;7(6): p553-60. Review.
  
  
• Orgel JP, Irving TC, Miller A, Wess TJ. Microfibrillar structure of type I collagen in situ. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24): p9001-5.
  
  
• Orgel JP. Sequence context and modified hydrophobic moment plots help identify 'horizontal' surface helices in transmembrane protein structure prediction. J Struct Biol. 2004 Oct;148(1): p51-65.
  
  

---

---

Molecular Biochemistry and Biophysics Division, 3101 South Dearborn St., Chicago, IL 60616
Phone: 312.567.3480     FAX: 312.567.3494
Molecular Biochemistry and Biophysics Webmaster (segre@iit.edu)