Konstantinos Arfanakis

  • Professor of Biomedical Engineering
  • Director of the MRI Program at the Pritzker Institute


Ph.D., Medical Physics, University of Wisconsin-Madison, Wisconsin, 2002
M.S., Medical Physics, University of Wisconsin-Madison, Wisconsin, 1999
B.S., Physics, University of Athens, Greece, 1997

Research Interests

Current Projects

Development of human brain atlases

Multi-parametric MRI in aging and dementia

Ex-vivo human brain MRI


Professional Affiliations & Memberships

International Society for Magnetic Resonance in Medicine (ISMRM) (1998-present)

The American Association of Physicists in Medicine (AAPM) (2008-present)

American Society of Neuroradiology (ASNR) (2008-2014)

Sigma Xi (2007-2012)

Organization for Human Brain Mapping (OHBM) (2006-2010)

New York Academy of Sciences (NYAS) (2005)


Merit Abstract Award, Organization for Human Brain Mapping (2015).

Journal article Nat Genet 2012;44:545-552, received the “Best paper” award for the 2012 de Leon Prize in Neuroimaging.

ISMRM Magna Cum Laude Merit Award, International Society for Magnetic Resonance in Medicine (ISMRM) (2012).

Journal article Am. J. Neuroradiol. 2002; 23: 794-802, was ranked #28 Most Frequently Cited Article in the history of the journal (2010 rankings).

Journal article Neuroimage 2009;46:967-980 was ranked 11th in the list of “hottest articles” in Neuroimage for April-June 2009.

Sigma Xi Award for Excellence in University Research, 2007.

Journal article Magn. Reson. Med. 2002;47:354-363 was ranked in the Top 10 most accessed papers in Magnetic Resonance in Medicine for the period 2002-2003.

International Society for Magnetic Resonance in Medicine (ISMRM) Stipend, 1999 - 2002

Magna Cum Laude, Radiological Society of North America (RSNA), 2002

Excellence in Design of Education Exhibit, Radiological Society of North America (RSNA), 2002

Vilas Fellowship, 2001


Peer reviewed articles

  1. G. Chauhan, H.H.H. Adams, J.C. Bis, G. Weinstein, L. Yu, A.M. Töglhofer, A.V. Smith, S. van der Lee, R.F. Gottesman, R. Thomson, J. Wang, Q. Yang, W.J. Niessen, O.L. Lopez, J.T. Becker, T.G. Phan, R.J. Beare, K. Arfanakis, D. Fleischman, M.W. Vernooij, B. Mazoyer, H. Schmidt, V. Srikanth, D.S. Knopman, C.R. Jack Jr., P. Amouyel, A. Hofman. Association of Alzheimer disease GWAS loci with MRI-markers of brain aging. Neurobiol Aging 2015;36:1765.e7-1765.e16.
  2. J.S. Yokoyama, V.E. Sturm, L.W. Bonham, E. Klein, K. Arfanakis, L. Yu, G. Coppola, J.H. Kramer, D.A. Bennett, B.L. Miller, D.B. Dubal. Variation in longevity gene KLOTHO is associated with greater cortical volumes. Annals of Clinical and Translational Neurology 2015;2:215-230.
  3. D.A. Fleischman, J. Yang, K. Arfanakis, Z. Arvanitakis, S.E. Leurgans, A.D. Turner, L.L. Barnes, D.A. Bennett, A.S. Buchman. Physical activity, motor function, and white matter hyperintensity burden in healthy older adults. Neurology 2015;84:1294-1300.
  4. S.D. Han, P.A. Boyle, L. Yu, D.A. Fleischman, K. Arfanakis, S. Leurgans, D.A. Bennett. Financial literacy is associated with medial brain region functional connectivity in old age. Arch Gerontol Geriatr 2014;59:429-438.
  5. S. Zhang, K. Arfanakis. White matter segmentation based on a skeletonized atlas: Effects on diffusion tensor imaging studies of regions of interest. J Magn Reson Imaging 2014;40:1189-1198.
  6. D.A. Fleischman, S. Leurgans, K. Arfanakis, Z. Arvanitakis, L.L. Barnes, P.A. Boyle, S.D. Han, D.A. Bennett. Gray-matter macrostructure in cognitively healthy older persons: associations with age and cognition. Brain Struct Funct 2014;219:2029-2049.
  7. R.J. Dawe, D.A. Bennett, J.A. Schneider, S.E. Leurgans, A. Kotrotsou, P.A. Boyle, K. Arfanakis. Ex-vivo T2 relaxation: Associations with age-related neuropathology and cognition. Neurobiol Aging 2014;35:1549-1561.
  8. A. Varentsova, S. Zhang, K. Arfanakis. Development of a high angular resolution diffusion imaging human brain template. Neuroimage 2014;91:177-186.
  9. Kotrotsou, D.A. Bennett, J.A. Schneider, R.J. Dawe, T. Golak, S.E. Leurgans, L. Yu, K. Arfanakis. Ex-vivo MR Volumetry of Human Brain Hemispheres. Magn Reson Med 2014;71:364-374.
  10. S.D. Han, P.A. Boyle, D.A. Fleischman, K. Arfanakis, D.A. Bennett. Ventromedial PFC, parahippocampal, and cerebellar connectivity are associated with temporal discounting in old age. Exp Gerontol 2013;48:1489-1498.
  11. K. Arfanakis, D.A. Fleischman, G. Grisot, C.M. Barth, A. Varentsova, M.C. Morris, L.L. Barnes, D.A. Bennett. Systemic Inflammation in Non-Demented Elderly Human Subjects: Brain Microstructure and Cognition. PLoS ONE 2013;8:e73107.
  12. S.D. Han, A.S. Buchman, K. Arfanakis, D.A. Fleischman, D.A. Bennett. Functional Connectivity Networks Associated With Chronic Musculoskeletal Pain in Old Age. Int J Geriatr Psychiatry 2013;28:858-867.
  13. D.A. Fleischman, L. Yu, K. Arfanakis, S.D. Han, L.L. Barnes, Z. Arvanitakis, P.A. Boyle, D.A. Bennett. Faster cognitive decline in the years prior to MR imaging is associated with smaller hippocampal volumes in cognitively healthy older persons. Front Aging Neurosci 2013;5:21.
  14. S. Zhang, K. Arfanakis. Role of standardized and study-specific human brain diffusion tensor templates in inter-subject spatial normalization. J Magn Reson Imaging 2013;37:372-381.
  15. A.A. Tamhane, K. Arfanakis, M. Anastasio, X. Guo, M. Vannier, J.H. Gao. Rapid PROPELLER-MRI: A combination of iterative reconstruction and under-sampling. J Magn Reson Imaging 2012;36:1241-1247.
  16. Z. Arvanitakis, R.L. Brey, J.H. Rand, J.A. Schneider, S.E. Leurgans, L. Yu, A.S. Buchman, K. Arfanakis, D.A. Fleischman, P.A. Boyle, D.A. Bennett, S.R. Levine. Antiphospholipid Antibodies, Brain Infarcts, and Cognitive and Motor Decline in Aging (ABICMA): Design of a Community-Based, Longitudinal, Clinical-Pathological Study. Neuroepidemiology 2013;40:73-84.
  17. Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium, J.C. Bis, C. Decarli, A.V. Smith, F. van der Lijn, F. Crivello, M. Fornage, S. Debette, J.M. Shulman, H. Schmidt, V. Srikanth, M. Schuur, L. Yu, S.H. Choi, S. Sigurdsson, B.F. Verhaaren, A. L. Destefano, J.C. Lambert, C.R. Jack, M. Struchalin, J. Stankovich, C.A. Ibrahim-Verbaas, D. Fleischman, A. Zijdenbos, T. den Heijer, B. Mazoyer, L.H. Coker, C. Enzinger, P. Danoy, N. Amin, K. Arfanakis, M.A. van Buchem, R.F. de Bruijn, A. Beiser, C. Dufouil, J. Huang, M. Cavalieri, R. Thomson, W.J. Niessen, L.B. Chibnik, G.K. Gislason, A. Hofman, A. Pikula, P. Amouyel, K.B. Freeman, T.G. Phan, B.A. Oostra, J.L. Stein, S.E. Medland, A.A. Vasquez, D.P. Hibar, M.J Wright, B. Franke, N.G. Martin, P.M. Thompson; the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, M.A. Nalls, A.G. Uitterlinden, R. Au, A. Elbaz, R.J. Beare, J.C. van Swieten, O.L. Lopez, T.B. Harris, V. Chouraki, M.M. Breteler, P.L. De Jager, J.T. Becker, M.W. Vernooij, D. Knopman, F. Fazekas, P.A. Wolf, A. van der Lugt, V. Gudnason, W.T. Longstreth, M.A. Brown, D.A. Bennett, C.M. van Duijn, T.H. Mosley, R. Schmidt, C. Tzourio, L.J. Launer, M.A. Ikram, S. Seshadri. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nat Genet 2012;44:545-552.
  18. Y. Wang, J.D. West, L.A. Flashman, H.A. Wishart, R.B. Santulli, L.A. Rabin, N. Pare, K. Arfanakis, A.J. Saykin. Selective Changes in White Matter Integrity in MCI and Older Adults with Cognitive Complaints. Biochim Biophys Acta 2012;1822:423-430.
  19. S.D. Han, P.A. Boyle, K. Arfanakis, D.A. Fleischman, L. Yu, E.C. Edmonds, D.A. Bennett. Neural intrinsic connectivity networks associated with risk aversion in old age. Behav Brain Res 2012;227:233-240.
  20. S.D. Han, K. Arfanakis, D.A. Fleischman, S.E. Leurgans, E.R. Tuminello, E. Edmonds, D.A. Bennett. Functional Connectivity Variations in Mild Cognitive Impairment: Associations with Cognitive Function. J Int Neuropsychol Soc 2012;18:39-48.
  21. R.J. Dawe, D.A. Bennett, J.A. Schneider, K. Arfanakis. Neuropathologic correlates of hippocampal atrophy in the elderly: A clinical, pathologic, postmortem MRI study. PLoS ONE 2011;6:e26286.
  22. S. Zhang, H. Peng, R.J. Dawe, K. Arfanakis. Enhanced ICBM Diffusion Tensor Template of the Human Brain. Neuroimage 2011;54:974-984.
  23. D.A. Fleischman, K. Arfanakis, J.F. Kelly, N. Rajendran, A.S. Buchman, M.C. Morris, L.L. Barnes, D.A. Bennett. Regional cortical thinning and systemic inflammation in older persons without dementia. J Am Geriatr Soc 2010;58;1823-1825.
  24. A.A. Tamhane, M.A. Anastasio, M. Gui, K. Arfanakis. Iterative image reconstruction for PROPELLER-MRI using the non-uniform fast Fourier transform. J Magn Reson Imaging 2010;32:211-217.
  25. K.L. Phan, A. Orlichenko, E. Boyd, M. Angstadt, E.F. Coccaro, I. Liberzon, K. Arfanakis. Preliminary evidence of white matter abnormality in the uncinate fasciculus in generalized social anxiety disorder. Biol Psychiatry 2009;66:691-694.
  26. A.A. Tamhane, K. Arfanakis. Motion correction in PROPELLER and Turboprop-MRI. Magn Reson Med 2009;62:174-182.
  27. H. Peng, A. Orlichenko, R.J. Dawe, G. Agam, S. Zhang, K. Arfanakis. Development of a human brain diffusion tensor template. Neuroimage 2009;46:967-980.
  28. R.J. Dawe, D.A. Bennett, J.A. Schneider, S.K. Vasireddi, K. Arfanakis. Post-mortem MRI of Human Brain Hemispheres: T2 Relaxation Times during Formaldehyde Fixation. Magn Reson Med 2009;61:810-818.
  29. M. Gui, H. Peng, J.D. Carew, M.S. Lesniak, K. Arfanakis. A tractography comparison between Turboprop and spin-echo echo-planar diffusion tensor imaging. Neuroimage 2008;42:1451-1462.
  30. M. Gui, A.A. Tamhane, K. Arfanakis. Contribution of Cardiac-Induced Brain Pulsation to the Noise of the Diffusion Tensor in Turboprop-DTI. J Magn Reson Imaging 2008;27:1164-1168.
  31. K. Arfanakis, M. Gui, A.A. Tamhane, J.D. Carew. Investigating the Medial Temporal Lobe in Alzheimer’s Disease and Mild Cognitive Impairment, with Turboprop Diffusion Tensor Imaging, MRI-Volumetry and T2-relaxometry. Brain Imaging and Behav 2007;1:11-21.
  32. A.S. Lukic, M.N. Wernick, Y. Yang, L.K. Hansen, K. Arfanakis, S.C. Strother. Effect of spatial alignment transformations in PCA and ICA of functional neuroimages. IEEETrans Med Imaging 2007;26:1058-1068 .
  33. H. Peng, K. Arfanakis. Diffusion tensor encoding schemes optimized for white matter fibers with selected orientations. Magn Reson Imaging 2007;25:147-153.
  34. K. Arfanakis, M. Gui, M. Lazar. Optimization of white matter tractography for pre-surgical planning. Oncol Rep 2006;15:1061-1064.
  35. K. Arfanakis, M. Gui, M. Lazar. White matter tractography by means of Turboprop diffusion tensor imaging. Ann N Y Acad Sci 2005;1064:78-87.
  36. K. Arfanakis, A.A. Tamhane, J.G. Pipe, M.A. Anastasio. K-space under-sampling in PROPELLER imaging. Magn Reson Med 2005;53:675-683.
  37. R.A. Hurley, J.C. McGowan, K. Arfanakis, K.H. Taber. Traumatic axonal injury: novel insights into evolution and identification. (Review). J Neuropsychiatry Clin Neurosci 2004;16:1-7.
  38. A.S. Field, K. Hasan, B.J Jellison, K. Arfanakis, A.L. Alexander. Diffusion tensor imaging in an infant with traumatic brain swelling. AJNR Am J Neuroradiol 2003;24:1461-1464.
  39. M. Lazar, D.M. Weinstein, J.S. Tsuruda, K.M. Hasan, K. Arfanakis, M.E. Meyerand, B. Badie, H.A. Rowley, V.M. Haughton, A.S. Field, A.L. Alexander. White matter tractography using tensor deflection. Hum Brain Mapp 2003;18:306-321.
  40. B.P. Rogers, V.M. Haughton, K. Arfanakis, M.E. Meyerand. Application of image registration to measurement of intervertebral rotation in the lumbar spine. Magn Reson Med 2002;48:1072-1075.
  41. B.P. Witwer, R. Moftakhar, K.M. Hasan, P. Deshmukh, V.M. Haughton, A.S. Field, K. Arfanakis, J. Noyes, C.H. Moritz, M.E. Meyerand, H.A. Rowley, A.L. Alexander, B. Badie. Diffusion tensor imaging of white matter tracts in patients with cerebral neoplasms. J Neurosurg 2002;97(3):568-575.
  42. D. Cordes, V.M. Haughton, J.D. Carew, K. Arfanakis, K. Maravilla. Hierarchical clustering to measure connectivity in fMRI resting-state data. Magn Reson Imaging 2002;20:305-317.
  43. K. Arfanakis, B.P Hermann, B.P. Rogers, J.D. Carew, M. Seidenberg, M.E. Meyerand. Diffusion tensor MRI in temporal lobe epilepsy. Magn Reson Imaging 2002;20:511-519.
  44. A.R. Laird, B.P. Rogers, J.D. Carew, K. Arfanakis, C.H. Moritz, M.E. Meyerand. Characterizing instantaneous phase relationships in whole-brain fMRI activation data. Hum Brain Mapp 2002;16:71-80.
  45. K. Arfanakis, V.M. Haughton, J.D. Carew, B.P. Rogers, R.J. Dempsey, M.E. Meyerand. Diffusion tensor MRI in diffuse axonal injury. AJNR Am J Neuroradiol 2002;23:794-802.
  46. K. Arfanakis, D. Cordes, V.M. Haughton, J.D. Carew, M.E. Meyerand. Independent component analysis applied to diffusion tensor MRI. Magn Reson Med 2002;47:354-363.
  47. D. Cordes, V.M. Haughton, K. Arfanakis, J.D. Carew, P.A. Turski, C.H. Moritz, MA. Quigley, M.E. Meyerand. Frequencies contributing to functional connectivity in the cerebral cortex in “resting-state” data. AJNR Am J Neuroradiol 2001;22:1326-1333.
  48. K. Arfanakis, D. Cordes, V.M. Haughton, C.H. Moritz, M.A. Quigley, M.E. Meyerand. Combining independent component analysis and correlation analysis to probe interregional connectivity in fMRI task activation datasets. Magn Reson Imaging 2000;18:921-930.
  49. D. Cordes, V.M. Haughton, K. Arfanakis, G.J. Wendt, P.A. Turski, C.H. Moritz, M.A. Quigley, M.E. Meyerand. Mapping functionally related regions of brain with functional connectivity MR Imaging. AJNR Am J Neuroradiol 2000;21:1636-1644.


  1. D.C. Karampinos, R.J. Dawe, K. Arfanakis, J.G. Georgiadis. Optimal diffusion encoding strategies for fiber mapping in diffusion MRI. In Handbook of Research on Advanced Techniques in Diagnostic Imaging and Biomedical Applications, IGI Global, 2009, pp 90-107.
  2. V.M. Haughton, C. Moritz, M.E. Meyerand, K. Arfanakis, D. Cordes. Mapping brain function with functional magnetic resonance imaging. In Imaging of the Nervous System: Diagnostic and Therapeutic Applications, Philadelphia, PA, Elsevier Publishing-Mosby, 2005, pp 89-100.
  3. K. Arfanakis, B.P. Hermann. Diffusion and perfusion MR imaging in seizure disorders. In Clinical MR Neuroimaging, 2nd Edition, Cambridge University Press, 2010, pp 546-556.
  4. K. Arfanakis, B.P. Hermann. Diffusion and perfusion MR imaging in seizure disorders. In Clinical MR Neuroimaging: Diffusion, Perfusion and Spectroscopy, Cambridge University Press, 2005, pp 509-520.


Magnetic resonance imaging (MRI), MRI data acquisition and image reconstruction, neuroimaging