Konstantinos Arfanakis

  • Professor of Biomedical Engineering
  • Director of the MRI Program at the Pritzker Institute


Ph.D., Medical Physics, University of Wisconsin-Madison, Wisconsin, 2002
M.S., Medical Physics, University of Wisconsin-Madison, Wisconsin, 1999
B.S., Physics, University of Athens, Greece, 1997

Research Interests

  1. Development of human brain atlases
  2. Development of MRI-based biomarkers of age-related neuropathologies
  3. Multi-parametric MRI in aging and dementia
  4. Ex-vivo human brain MRI

Professional Affiliations & Memberships

Core Leader, Neuroimaging Core, Rush Alzheimer’s Disease Center, 2017-present

International Society for Magnetic Resonance in Medicine (ISMRM), 1998-present

The American Association of Physicists in Medicine (AAPM), 2008-present

Rush Alzheimer’s Disease Center (RADC), Rush University Medical Center, 2006-present

American Society of Neuroradiology (ASNR), 2008-2014

Sigma Xi, 2007-2012

Organization for Human Brain Mapping (OHBM), 2006-2010, 2017, 2019

New York Academy of Sciences (NYAS), 2005


ISMRM Magna Cum Laude Merit Award, 27th Annual ISMRM international conference, 2019

Best Nursing Abstract, American Heart Association Scientific Sessions, 2017

ISMRM Magna Cum Laude Merit Award, 25th Annual ISMRM international conference, 2017

ISMRM Summa Cum Laude Merit Award, 23rd Annual ISMRM international conference, 2015

Merit Abstract Award, Organization for Human Brain Mapping, 2015

Journal article Nat Genet 2012;44:545-552, received the “Best paper” award for the de Leon Prize in Neuroimaging, 2012

ISMRM Magna Cum Laude Merit Award, International Society for Magnetic Resonance in Medicine, 2012

Journal article Am. J. Neuroradiol. 2002; 23: 794-802, was ranked #28 Most Frequently Cited Article in the history of the journal, 2010

Journal article Neuroimage 2009;46:967-980 was ranked 11th in the list of “hottest articles” in Neuroimage, April-June 2009

Sigma Xi Award for Excellence in University Research, 2007

Journal article Magn. Reson. Med. 2002;47:354-363 was ranked in the Top 10 most accessed papers in Magnetic Resonance in Medicine, 2002-2003

International Society for Magnetic Resonance in Medicine (ISMRM) Stipend, 1999 - 2002

Magna Cum Laude, Radiological Society of North America (RSNA), 2002

Excellence in Design of Education Exhibit, Radiological Society of North America (RSNA), 2002

Vilas Fellowship, 2001


90+ publications including:

X. Qi, K. Arfanakis. Regionconnect: Rapidly extracting standardized brain connectivity information in voxel-wise neuroimaging studies. Neuroimage. 2021;225:117462.

C. Javierre-Petit, J.A. Schneider, A. Kapasi, N. Makkinejad, A.A. Tamhane, S.E. Leurgans, R.I. Mehta, L.L. Barnes, D.A. Bennett, K. Arfanakis. Neuropathologic and Cognitive Correlates of Enlarged Perivascular Spaces in a Community-Based Cohort of Older Adults. Stroke. 2020;51:2825-2833.

K. Arfanakis, A.M. Evia, S.E. Leurgans, L.F.C. Cardoso, A. Kulkarni, N. Alqam, L.F. Lopes, D. Vieira, D.A. Bennett, J.A. Schneider. Neuropathologic Correlates of White Matter Hyperintensities in a Community-Based Cohort of Older Adults. J Alzheimers Dis. 2020;73:333-345.

P.T. Nelson, D.W. Dickson, J.Q. Trojanowski, C.R. Jack, P.A. Boyle, K. Arfanakis, R. Rademakers, I. Alafuzoff, J. Attems, C. Brayne, I.T.S. Coyle-Gilchrist, H.C. Chui, D.W. Fardo, M.E. Flanagan, G. Halliday, S.R.K. Hokkanen, S. Hunter, G.A. Jicha, Y. Katsumata, C.H. Kawas C.D. Keene, G.G. Kovacs, W.A. Kukull, A.I. Levey, N. Makkinejad, T.J. Montine, S. Murayama, M.E. Murray, S. Nag, R.A. Rissman, W.W. Seeley, R.A. Sperling, Iii C.L. White, L. Yu, J.A. Schneider. Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain 2019;142:1503-1527.

N. Makkinejad, J.A. Schneider, J. Yu, S.E. Leurgans, A. Kotrotsou, A.M. Evia, D.A. Bennett, K. Arfanakis. Associations of amygdala volume and shape with transactive response DNA-binding protein 43 (TDP-43) pathology in a community cohort of older adults. Neurobiol Aging 2019;77:104-111.

S. Zhang, K. Arfanakis. Evaluation of standardized and study-specific diffusion tensor imaging templates of the adult human brain: Template characteristics, spatial normalization accuracy, and detection of small inter-group FA differences. Neuroimage 2018;172:40-50.

A.M. Evia, A. Kotrotsou, A.A. Tamhane, R.J. Dawe, A. Kapasi, S.E. Leurgans, J.A. Schneider, D.A. Bennett, K. Arfanakis. Ex-vivo quantitative susceptibility mapping of human brain hemispheres. PLoS One 2017;12:e0188395.

S. Halloway, J. Wilbur, M.E. Schoeny, K. Arfanakis. Effects of Endurance-Focused Physical Activity Interventions on Brain Health: A Systematic Review. Biol Res Nurs (in press).

S.D. Han, P.A. Boyle, K. Arfanakis, D.A. Fleischman, L. Yu, B.D. James, D.A. Bennett. Financial literacy is associated with white matter integrity in old age. Neuroimage 2016;130:223-229.

K. Arfanakis, R.S. Wilson, C.M. Barth, A.W. Capuano, A. Vasireddi, S. Zhang, D.A. Fleischman, D.A. Bennett. Cognitive activity, cognitive function, and brain diffusion characteristics in old age. Brain Imaging Behav 2016;10:455-463.

A. Kotrotsou, J.A. Schneider, D.A. Bennett, S.E. Leurgans, R.J. Dawe, P.A. Boyle, T. Golak, K. Arfanakis. Neuropathologic Correlates of Regional Brain Volumes in a Community Cohort of Older Adults. Neurobiol Aging 2015;36:2798-2805.

D.A. Fleischman, J. Yang, K. Arfanakis, Z. Arvanitakis, S.E. Leurgans, A.D. Turner, L.L. Barnes, D.A. Bennett, A.S. Buchman. Physical activity, motor function, and white matter hyperintensity burden in healthy older adults. Neurology 2015;84:1294-1300.

S. Zhang, K. Arfanakis. White matter segmentation based on a skeletonized atlas: Effects on diffusion tensor imaging studies of regions of interest. J Magn Reson Imaging 2014;40:1189-1198.

R.J. Dawe, D.A. Bennett, J.A. Schneider, S.E. Leurgans, A. Kotrotsou, P.A. Boyle, K. Arfanakis. Ex-vivo T2 relaxation: Associations with age-related neuropathology and cognition. Neurobiol Aging 2014;35:1549-1561.

A. Varentsova, S. Zhang, K. Arfanakis. Development of a high angular resolution diffusion imaging human brain template. Neuroimage 2014;91:177-186.

A. Kotrotsou, D.A. Bennett, J.A. Schneider, R.J. Dawe, T. Golak, S.E. Leurgans, L. Yu, K. Arfanakis. Ex-vivo MR Volumetry of Human Brain Hemispheres. Magn Reson Med 2014;71:364-374.

K. Arfanakis, D.A. Fleischman, G. Grisot, C.M. Barth, A. Varentsova, M.C. Morris, L.L. Barnes, D.A. Bennett. Systemic Inflammation in Non-Demented Elderly Human Subjects: Brain Microstructure and Cognition. PLoS ONE 2013;8:e73107.

S. Zhang, K. Arfanakis. Role of standardized and study-specific human brain diffusion tensor templates in inter-subject spatial normalization. J Magn Reson Imaging 2013;37:372-381.

R.J. Dawe, D.A. Bennett, J.A. Schneider, K. Arfanakis. Neuropathologic correlates of hippocampal atrophy in the elderly: A clinical, pathologic, postmortem MRI study. PLoS ONE 2011;6:e26286.

S. Zhang, H. Peng, R.J. Dawe, K. Arfanakis. Enhanced ICBM Diffusion Tensor Template of the Human Brain. Neuroimage 2011;54:974-984.

A.A. Tamhane, M.A. Anastasio, M. Gui, K. Arfanakis. Iterative image reconstruction for PROPELLER-MRI using the non-uniform fast Fourier transform. J Magn Reson Imaging 2010;32:211-217.

A.A. Tamhane, K. Arfanakis. Motion correction in PROPELLER and Turboprop-MRI. Magn Reson Med 2009;62:174-182.

H. Peng, A. Orlichenko, R.J. Dawe, G. Agam, S. Zhang, K. Arfanakis. Development of a human brain diffusion tensor template. Neuroimage 2009;46:967-980.

R.J. Dawe, D.A. Bennett, J.A. Schneider, S.K. Vasireddi, K. Arfanakis. Post-mortem MRI of Human Brain Hemispheres: T2 Relaxation Times during Formaldehyde Fixation. Magn Reson Med 2009;61:810-818.

M. Gui, H. Peng, J.D. Carew, M.S. Lesniak, K. Arfanakis. A tractography comparison between Turboprop and spin-echo echo-planar diffusion tensor imaging. Neuroimage 2008;42:1451-1462.

M. Gui, A.A. Tamhane, K. Arfanakis. Contribution of Cardiac-Induced Brain Pulsation to the Noise of the Diffusion Tensor in Turboprop-DTI. J Magn Reson Imaging 2008;27:1164-1168.

K. Arfanakis, M. Gui, A.A. Tamhane, J.D. Carew. Investigating the Medial Temporal Lobe in Alzheimer’s Disease and Mild Cognitive Impairment, with Turboprop Diffusion Tensor Imaging, MRI-Volumetry and T2-relaxometry. Brain Imaging and Behav 2007;1:11-21.

H. Peng, K. Arfanakis. Diffusion tensor encoding schemes optimized for white matter fibers with selected orientations. Magn Reson Imaging 2007;25:147-153.

K. Arfanakis, A.A. Tamhane, J.G. Pipe, M.A. Anastasio. K-space under-sampling in PROPELLER imaging. Magn Reson Med 2005;53:675-683.

K. Arfanakis, B.P Hermann, B.P. Rogers, J.D. Carew, M. Seidenberg, M.E. Meyerand. Diffusion tensor MRI in temporal lobe epilepsy. Magn Reson Imaging 2002;20:511-519.

K. Arfanakis, V.M. Haughton, J.D. Carew, B.P. Rogers, R.J. Dempsey, M.E. Meyerand. Diffusion tensor MRI in diffuse axonal injury. AJNR Am J Neuroradiol 2002;23:794-802.

K. Arfanakis, D. Cordes, V.M. Haughton, J.D. Carew, M.E. Meyerand. Independent component analysis applied to diffusion tensor MRI. Magn Reson Med 2002;47:354-363.

D. Cordes, V.M. Haughton, K. Arfanakis, J.D. Carew, P.A. Turski, C.H. Moritz, MA. Quigley, M.E. Meyerand. Frequencies contributing to functional connectivity in the cerebral cortex in “resting-state” data. AJNR Am J Neuroradiol 2001;22:1326-1333.

K. Arfanakis, D. Cordes, V.M. Haughton, C.H. Moritz, M.A. Quigley, M.E. Meyerand. Combining independent component analysis and correlation analysis to probe interregional connectivity in fMRI task activation datasets. Magn Reson Imaging 2000;18:921-930.

D. Cordes, V.M. Haughton, K. Arfanakis, G.J. Wendt, P.A. Turski, C.H. Moritz, M.A. Quigley, M.E. Meyerand. Mapping functionally related regions of brain with functional connectivity MR Imaging. AJNR Am J Neuroradiol 2000;21:1636-1644.


  1. D.C. Karampinos, R.J. Dawe, K. Arfanakis, J.G. Georgiadis. Optimal diffusion encoding strategies for fiber mapping in diffusion MRI. In Handbook of Research on Advanced Techniques in Diagnostic Imaging and Biomedical Applications, IGI Global, 2009, pp 90-107.
  2. V.M. Haughton, C. Moritz, M.E. Meyerand, K. Arfanakis, D. Cordes. Mapping brain function with functional magnetic resonance imaging. In Imaging of the Nervous System: Diagnostic and Therapeutic Applications, Philadelphia, PA, Elsevier Publishing-Mosby, 2005, pp 89-100.
  3. K. Arfanakis, B.P. Hermann. Diffusion and perfusion MR imaging in seizure disorders. In Clinical MR Neuroimaging, 2nd Edition, Cambridge University Press, 2010, pp 546-556.
  4. K. Arfanakis, B.P. Hermann. Diffusion and perfusion MR imaging in seizure disorders. In Clinical MR Neuroimaging: Diffusion, Perfusion and Spectroscopy, Cambridge University Press, 2005, pp 509-520.

Editorial Boards

Associate Editor, “Journal of Alzheimer’s Disease”, published by IOS Press, 2020-2021

Editorial Board, Journal “Brain Imaging and Behavior”, published by Springer, 2006-present  


Magnetic resonance imaging (MRI), MRI data acquisition and image reconstruction, neuroimaging