Ali Cinar

  • Professor of Chemical Engineering
  • Director of the Engineering Center for Diabetes Research and Education
  • Hyosung S. R. Cho Endowed Chair in Engineering


Ph.D. from Texas A & M University (Chemical Engineering, 1976)
M. Eng. from Texas A & M University (Chemical Engineering, 1973)
B.S. from Robert College, Istanbul, Turkey (Chemical Engineering, 1970)

Research Interests

Professor Cinar's research activities are concentrated in three areas: complex adaptive agent-based systems, modeling, simulation and control of biomedical systems, and supervision of manufacturing process operations. The research activities focus on the development of theory, methodology, and tools that are used in various chemical, biochemical, pharmaceutical and biomedical systems.

Complex Adaptive Agent-Based Systems

  • Hierarchical multi-agent systems for modeling, supervision, and control of distributed complex adaptive systems

Modeling, Simulation and Control of Biomedical Systems

  • Artificial pancreas systems for patients with type 1 diabetes
  • Stochastic agent-based modeling of angiogenesis and tissue growth
  • Dynamic models and simulation of glucose and insulin variations in patients with diabetes, effects of exercise, hypoglycemia alarm systems
  • Metabolic pathway models for glucose utilization in muscle cells

Supervision of Manufacturing Process Operations

  • Multivariable process monitoring, performance assessment, and fault diagnosis
  • Nonlinear and multivariable process model development
  • Knowledge-based systems for supervisory control and intelligent process operations
  • Fault-tolerant control systems

Professional Affiliations & Memberships

Fellow of the American Institute of Chemical Engineers

American Diabetes Association

American Society for Engineering Education

Biomedical Engineering Society

Institute of Electrical and Electronics Engineers (Control System Society, Engineering in Medicine and Biology Society, and Systems, Man, and Cybernetics Society)


2005 - Fellow, American Institute of Chemical Engineers (AIChE)

2003 - Ernst W. Thiele Award, Chicago Section of AIChE

1996 - W. M. Langdon Award for Excellence in Teaching

1992-1993 - ASA/NSF/NIST Senior Research Fellow

1987 - W. M. Langdon Award for Excellence in Teaching


Turksoy, K, ES Bayrak, E Littlejohn, L Quinn and A Cinar: Multivariable Adaptive Closed-Loop Control of an Artificial Pancreas without Meal and Activity Announcement, Diabetes Technol. Therapeutics, 15(5) 386-400, 2013.

Turksoy, K, ES Bayrak, E Littlejohn, L Quinn and A Cinar: Hypoglycemia Early Alarm Systems Based on Multivariable Models, Industrial and Engineering Chemistry Research, doi: 10.1021/ie3034015, 2013.

Mehdizadeh, M, S Somo, ES Bayrak, EM Brey, and A Cinar: Three-dimensional Modeling of Angiogenesis in Porous Biomaterial Scaffolds, Biomaterials, DOI: 10.1016/j.biomaterials.2012.12.047, 34(12) 2875-2887, 2013.

Eren-Oruklu, M, A Cinar, D Rollins, and L Quinn: Adaptive system identification for estimating future glucose concentrations and hypoglycemia alarms, Automatica, doi:10.1016/j.automatica.2012.05.076, 48(8), 1892-1897, 2012.

MacGregor, JF, and A Cinar: Monitoring, Fault Diagnosis, Fault-Tolerant Control and Optimization: Data Driven Methods, Computers and Chemical Engineering, 47, 111-120, 2012

Perk, S, QM Shao, F Teymour, and A Cinar: An Adaptive Fault-Tolerant Control Framework with Agent-Based Systems, International Journal of Robust and Nonlinear Control, doi: 10.1002/rnc.1812, 22, 43-67, 2012.

Artel, A, H Mehdizadeh, Y-C Chiu, EM Brey, and A Cinar: An Agent-Based Model for the Investigation of Neovascularization within Porous Scaffolds, Tissue Eng. Part A, 17(17-18), 2133-2141, 2011.

Perk, S., F Teymour, and A Cinar: An Adaptive Agent-Based System for Process Fault Classification and Diagnosis, Industrial and Engineering Chemistry Research, 50(15), 9138-9155, 2011. DOI: 10.1021/ie102058d.

Perk, S, F Teymour, and A Cinar: Statistical Monitoring of Complex Chemical Processes Using Agent-Based Systems, DOI: 10.1021/ie901368v, Industrial and Engineering Chemistry Research, 49, 5080-5093, 2010.

Eren-Oruklu, M, A Cinar, L Quinn, and D Smith: Adaptive Control Strategy for Regulation of Blood Glucose Levels in Patients with Type 1 Diabetes, J Process Control, 19, 1333-1346, 2009.

Tetiker, M. D., A. Artel, F. Teymour, and A. Cinar: Control of Grade Transitions in Distributed Chemical Reactor Networks - An Agent-Based Approach, Computers and Chemical Engineering, 32(9), 1984-1994, 2008.

Tatara, E, F Teymour, and A Cinar: Control of Complex Distributed Systems with Distributed Intelligent Agents, J Process Control, 17(5), 415-427, 2007.

Tatara, E., I. Birol, F. Teymour, and A. Cinar: Agent-based Control of Autocatalytic Replicators in Networks of Reactors, Computers and Chemical Engineering, 29(4) 807-815, 2005.

Schaefer, J and A Cinar: Multivariable MPC system performance assessment, monitoring, and diagnosis, J. of Process Control, 14(2), 113-129, 2004.

Undey, C, S Ertunc, and A Cinar: Online Batch/Fed-batch Process Performance Monitoring, Quality Prediction, and Variable-Contribution Analysis for Diagnosis, Industrial and Engineering Chemistry Research, 42(20), 4645-4658, 2003.

Erzen, C., G. Birol, and A. Cinar: Development and Implementation of an Educational Simulator: GLUCOSIM, Chemical Engineering Education, 37 (4), 300-305, 2003.

Undey, C. and A. Cinar: Statistical Monitoring of Multistage, Multiphase Batch Processes, IEEE Control Systems Magazine, 22(5), 40-52, 2002.

Birol, G. C. Undey and A. Cinar: A Modular Simulation Package for Fed-batch Fermentation: Penicillin Production, Computers and Chemical Engineering, 26(11), 1553-1565, 2002.

Negiz A and A Cinar: Statistical Monitoring of Multivariable Dynamic Processes with State Space Models, AIChE J., 43(8), 2002-2020, 1997.

Raich A. and A. Cinar: Statistical Process Monitoring and Disturbance Diagnosis in Multivariable Continuous Processes, AIChE J., 42(4), 995-1009, 1996.


Cinar, A., A. Palazoglu, and F. Kayihan: Chemical Process Performance Evaluation, CRC Press, Boca Raton, FL, 2007.

Cinar A., S. Parulekar, G. Birol, and C. Undey: Batch Fermentation: Modeling, Monitoring, Control, Marcel Dekker, New York, 2003